There are no dietary restrictions for people with Lesch-Nyhan disease. Some nutritionists recommend a "low purine" diet, but there is no evidence that the diet has any important influence on the condition.
Some people with Lesch-Nyhan disease trouble swallowing, and some have trouble with frequent vomiting. If there is trouble with swallowing, the food must be cut into small pieces or made into a soft consistency. Some even have trouble even with small bites and a soft consistency. If this trouble leads to weight loss, they may require a liquid diet through a special tube inserted directly into the stomach.